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In addition to being an antiviral therapeutic strategy, targeting autophagy may be a viable option for treating cancer patients with COVID-19 to reduce the risk of mortality, progression, chemotherapy resistance, and tumor recurrence in a variety of cancers [191] (Fig

Early trials have confirmed pharmacodynamic markers such as interferon induction, T cell activation and local remodeling of cytokine profiles, but durable survival benefits remain to be established [76, 81, 83]

In vitro studies further demonstrate that the cross-linked vesicles act as a reservoir, sustaining cumulative drug release over 48 h under intracellular-mimicking conditions